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. 2022 Mar 9;107(6):e2276–e2283. doi: 10.1210/clinem/dgac136

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© The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Independent genetic variants associated with free thyroxine (FT4) in 25 candidate genes. (A) List of included thyroid hormone-regulating candidate genes. Genes with at least 1 independent signal are depicted in bold. (B) The y-axis shows the number of independently associated genetic variants with serum FT4 concentrations per gene (x-axis). Only genes with at least 1 significant single nucleotide polymorphism (SNP) association are included. The novel variants are depicted in black, linkage disequilibrium (LD) correlated variants with a genome-wide association study (GWAS) loci outside the candidate gene region in grey and known top hits from GWAS are depicted in a striped pattern.