Table 2.

nMTR recovery in nMTR lesions (FAS ^a ).

	Siponimod (N = 413, N’ = 72)	Placebo (N = 226, N’ = 80)	Treatment difference (siponimod vs placebo)	p-value
nMTR drop (accounting for lesion volume)	−1.35	−1.71	0.36	<0.0001

FAS: full analysis set; MTR: magnetization transfer ratio; N: number of patients in MTR subset; N’: number of patients with at least one MTR lesion; nMTR: normalized magnetization transfer ratio.

nMTR drop (i.e. nMTR recovery metrics) describes the total decrease in nMTR from pre- to post-nMTR lesion time points. At least three MTR scans were needed: (1) to obtain a stable pre-lesion nMTR value; (2) to detect an acute drop in nMTR indicative of a newly forming lesion; and (3) to obtain a stable post-lesion nMTR value. In this analysis, the latest available measurement before the formation of a new lesion was taken as pre-lesion time point, and the latest available measurement after the formation of a new lesion was taken as the post-lesion time point. Peri-lesion time points were not included.

^aFAS included all randomized patients with assigned treatments who took at least one dose of study medication.