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. 2022 Apr 5;28(10):1591–1605. doi: 10.1177/13524585221083194

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© The Author(s), 2022

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 6. — Kaplan–Meier estimate of the time to 6-month confirmed clinically meaningful worsening in CPS in the combined core and extension parts (combined FAS—active SPMS).

Combined FAS includes all available SDMT data from the start of the core part to the cutoff date of the extension part. Subjects without baseline SDMT assessment were excluded from the analysis.

CCW: confirmed cognitive worsening; CI: confidence interval; CPS: cognitive processing speed; FAS: full analysis set; HR: hazard ratio; SDMT: Symbol Digit Modalities Test; SPMS: secondary progressive multiple sclerosis.