TABLE 2.

Hierarchical regression explaining variability in delayed episodic memory composite.

Delayed memory composite score	Independent variables	β	t-value	F	ΔF	R 2	ΔR2
Step 1				5.15**		0.09
	Age	–0.17	–1.74
	Sex	0.25	2.63**
Step 2				2.62*	0.18	0.09	0.00
	Age	–0.16	–1.60
	Sex	0.25	2.54**
	Aβ42/Aβ40	0.06	0.50
	P-tau181	0.001	0.01
Step 3				1.86	0.41	0.10	0.01
	Age	–0.18	–1.74
	Sex	0.21	1.89†
	Aβ42/Aβ40	0.05	0.42
	P-tau181	–0.01	–0.07
	Entorhinal volume	–0.05	–0.46
	Hippocampal volume	–0.08	–0.71
Step 4				2.94**	5.63**	0.20	0.10
	Age	0.02	0.17
	Sex	0.23	2.16*
	Aβ42/Aβ40	0.05	0.47
	P-tau181	–0.05	–0.47
	Entorhinal volume	–0.08	–0.73
	Hippocampal volume	–0.06	–0.55
	Fornix RD	–0.43	–2.93**
	Hippocampal cingulum RD	0.31	2.76**
Step 5				2.45**	1.54	0.26	0.06
	Age	0.04	0.32
	Sex	0.22	1.91†
	Aβ42/Aβ40	0.08	0.66
	P-tau181	–0.04	–0.30
	Entorhinal volume	–0.09	–0.84
	Hippocampal volume	–0.11	–0.93
	Fornix RD	–0.53	–3.41***
	Hippocampal cingulum RD	0.34	2.99**
	RS control	0.07	0.60
	RS default	0.01	0.12
	RS limbic	0.03	0.29
	RS dorsal attention	0.13	1.23
	RS salience	–0.28	–2.36*

^†p < 0.06; *p < 0.05; **p < 0.01; ***p < 0.001. RD, radial diffusivity; RS, resting state. Bolded values represent statistically significant findings.