Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jul 12;15:927479. doi: 10.3389/fnmol.2022.927479

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Ji, Tang, Chen, Wang, Tan, Liao, Tong and Xiao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Pathophysiology of motile cilia in hydrocephalus. Abnormal motile cilia can be caused by a variety of reasons. (A) Alcohol abuse may reduce the beating frequency of cilia, resulting in slower CSF flow. (B) Degenerative neuropathologies, such as Alzheimer’s disease, can obstruct the clearance of toxic molecules like Aβ, causing them to accumulate in the ventricle. (C) Furthermore, PCD patients’ ependymal cilia are unable to beat at a regular frequency, which contributes to a disruption in normal CSF circulation. (D) Concussion brain injury also contributes to the rapid shedding of ventricular ependymal cilia and the reduction of CSF flow frequency.