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. 2022 Jul 12;15:900057. doi: 10.3389/fnmol.2022.900057

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Copyright © 2022 Eide and Hansson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Aspects on the dynamics of astrocytes and neurons in the cerebral cortex of IIH patients. (A) Section of the subpial molecular cortex layer, which is dominated by astrocytes and have only scattered nerve cells. The GFAP-IR astrocytes (yellow arrow) are star-shaped with mainly slender radiating and non-dividing processes. Scattered nerve cells (red arrow) are seen in the neuropil. This illustrates the normal structure of cortex layer 1. (B) The astrocytes in this specimen of layer 1 are hypertrophic and their processes have abundancy of glio-filament (yellow arrow). The density of the GFAP-IR meshwork is increased in (B) as compared to (A). (C) A dense network of branching and prominently GFAP-IR processes of impressive density. (D) In cortex layers 2/3 of an IIH subject, NF-H-IR expression occurs in damaged or dying neurons (green arrows), while living neurons remain colorless (blue arrows). This indicates neuronal damage in IIH.