Table 1.
Variables indicative of idiopathic intracranial hypertension (IIH) pathophysiology in the 13 patients with definite IIH.
| IIH patient | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | |
| Demographic | |||||||||||||
| Gender | F | F | F | F | F | F | F | F | F | M | F | F | M |
| Age (yrs) | 38 | 30 | 22 | 34 | 24 | 48 | 37 | 47 | 22 | 21 | 24 | 52 | 31 |
| BMI (kg/m2) | 29 | 33 | 29 | 34 | 28 | 23 | 26 | 33 | 38 | 35 | 37 | 39 | 23 |
| Symptoms | |||||||||||||
| Headache | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Papilledema/Visual deficits | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Tinnitus | – | – | 1 | 1 | 1 | – | – | – | – | – | – | 1 | 1 |
| Cognitive impairment | 1 | 1 | – | – | 1 | 1 | 1 | – | – | – | – | 1 | – |
| MRI-evidence of CSF disturbance | |||||||||||||
| Empty sella/distended | |||||||||||||
| Perioptic subarachnoid space | 1 | – | – | – | 1 | 1 | – | – | 1 | – | – | 1 | 1 |
| MRI-Evidence of venous obstruction | |||||||||||||
| Sinus vein stenosis | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Overnight ICP | |||||||||||||
| Abnormal MWA | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Abnormal mean ICP | 1 | – | – | – | – | 1 | – | – | – | – | – | – | 1 |
| Ultrastructural abnormality at the glia-neuro-vascular interface | |||||||||||||
| Glial cells | |||||||||||||
| Astrocyte hypertrophy/loss of astrocyte domains | 1 | 1 | 1 | – | 1 | 1 | – | 1 | 1 | 1 | 1 | 1 | 1 |
| Patchy astrogliosis | 1 | 1 | – | – | – | 1 | – | – | 1 | – | 1 | 1 | – |
| Neurons | |||||||||||||
| Neurofilament-H | 1 | 1 | – | – | – | 1 | – | – | – | – | 1 | – | – |
| Synaptic stripping | 1 | – | – | – | – | 1 | – | 1 | 1 | – | 1 | – | – |
| Capillaries | |||||||||||||
| Degeneration of pericyte processes | 1 | – | – | – | 1 | 1 | 1 | 1 | 1 | 1 | 1 | – | – |
| BM vesicles/splitting | 1 | – | – | – | 1 | 1 | 1 | 1 | 1 | 1 | 1 | – | – |
| BBB leakage | 1 | – | – | – | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
BBB, blood-brain-barrier; BM, Basement membrane; BMI, body mass index; ICP, Intracranial pressure; MWA, mean; ICP, wave amplitude.