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. 2022 Jul 12;13:921337. doi: 10.3389/fphar.2022.921337

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Copyright © 2022 Wang, Wang, Guo, Liao, Chai, Wang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RDN could alleviate LPS-induced HUVECs apoptosis. (A,B) Immunofluorescence was performed to detect the level of apoptosis related protein. Magnification×40, scale bar 20 μm. (C-G) Flow cytometry was employed to detect apoptosis rate. Cells were equally divided into the Con group, LPS group, RDN group, LPS + RDN group and evaluated the proportion of apoptotic cells (Q2+Q3) in each group. Data are presented as mean ± SD (n = 3 per group) of the representative data from three independent experiments; **p < 0.01, ****p < 0.001.