TABLE 2.

MR estimates for each method to assess the effect of TL on skin aging and skin cancer.

Outcome	MR Methods	Number of SNPs	OR (95%CI)	SE	P
Neuroblastoma	MR-Egger	39	0.9639 (0.9332∼0.9956)	0.0164	0.03
	Weighted median	39	0.9799 (0.9632∼0.9969)	0.0087	0.01
Simple mode	Inverse variance weighted	39	0.9880 (0.9735∼1.003)	0.0075	0.11
	Maximum likelihood	39	0.9878 (0.9777∼0.9982)	0.0053	0.02
	Weighted mode	39	0.9758 (0.9582∼0.9900)	0.0200	0.01
	MR-Egger	38	1.0344 (1.0168∼1.0524)	0.0088	4.60E-04
	Weighted median	38	1.0231 (1.0138∼1.0324)	0.0045	1.19E-06
	Inverse variance weighted	38	1.0166 (1.0084∼1.0249)	0.0041	6.33E-05
	Maximum likelihood	38	1.0178 (1.0126∼1.0231)	0.0027	1.09E-10
	Weighted mode	38	1.0282 (1.0120∼1.0447)	0.0079	1.79E-03
melanoma	MR-Egger	38	1.0127 (1.0046∼1.0209)	0.0041	6.36E-07
	Weighted median	38	1.0057 (1.0019∼1.0095)	0.0019	4.99E-03
	Inverse variance weighted	38	1.0057 (1.0020∼1.0095)	0.0019	2.68E-03
	Maximum likelihood	38	1.0059 (1.0036∼1.0082)	0.0011	6.36E-07
	Weighted mode	38	1.0058 (1.0017∼1.0103)	0.0023	1.96E-02