TABLE 3.

Heterogeneity and pleiotropy analysis by MR Egger, IVW, Maximum likelihood.

Outcome	MR Methods	Cochran Q statistic	Heterogeneity p-value	Pleiotropy p-value
skin aging	MR-Egger	76.72	1.36E-04	0.10
	Inverse variance weighted	82.55	3.86E-05
	Maximum likelihood	82.30	4.15E-05
NMSCs	MR-Egger	82.02	1.90E-05	0.10
	Inverse variance weighted	93.12	9.78E-07
	Maximum likelihood	90.62	2.15E-06
melanoma	MR-Egger	97.10	1.62E-07	0.72
	Inverse variance weighted	106.60	1.15E-08
	Maximum likelihood	105.44	1.71E-08