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. 2022 Jul 12;13:923241. doi: 10.3389/fimmu.2022.923241

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Copyright © 2022 Shi, Zhao, Jiang, Wang, Wang, Kou and Yao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bioengineered mature vascularized scaffold (MVS) for islet transplantation. (A) Schematic illustration of the bioengineered vascularized islet organ for transplantation. (B) Image of a MVS’ cross-section after 7 days. (C) Left: Images of a mature MVS for transplantation. Right: MVS transplanted into the abdominal cavity. Pulmonary artery and pulmonary veins were connected to inferior vena cava (IVC) and aorta (Ao). (D) MVS preTx and 14 days after transplantation. Right top image, CD34⁺ vascular ingrowth very close to islet and human CD31⁺ region. Right down image, murine vascular network was preliminarily established inside MVS at 14 days post-transplantation. (E) Blood glucose levels after intravenous glucose tolerance test in diabetic rats 1 h after vascular anastomosis. (F) Non-fasting blood glucose measurements after islet transplantation over 30 days. Reproduced, with permission, from (85) Copyright (2019), Elsevier Ltd.