Table 1.
The application of immune inducing therapeutics in islet transplantation.
| Generic name | Trade name | Mechanism | Ref. |
|---|---|---|---|
| Antithymocyte globulin (ATG) | Thymoglobulin | Polyclonal antibody, profound T-cell depletion | (32) |
| Muromonab-CD3 | Orthoclone OKT3 | Anti-CD3 mAb, T-cell depletion | (33) |
| Alemtuzumab | CampathLemtrada | Anti-CD52 mAb, T-cell depletion | (34) |
| Basiliximab | Simulect | Anti-CD25 mAb IL-2 receptor antagonist | (35) |
| Daclizumab | Zenapax | Anti-CD25 mAb IL-2 receptor antagonist | (5) |
| Anti-CD154-mAb | – | Blockage of CD40/CD154 T-cell costimulation | (36) |