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. 2022 Jul 11;12:791332. doi: 10.3389/fonc.2022.791332

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Copyright © 2022 Mao, Yu, Wang, Ma, Zheng, Zhang, Luo, Wang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Conjoint analysis of MeRIP-seq and RNA-seq data. (A) Volcano plots showing the differentially expressed genes in tumor vs normal. (B) Heatmap plots showing the differentially expressed genes in tumor vs normal. (C) Four-quadrant plots showing the distribution of genes with significant changes in both the m6A modification and RNA levels. (D) The top 10 GO terms of genes with significant changes in both the m6A modification and mRNA levels. (E) The top 10 KEGG pathways of genes with significant changes in both the m6A modification and RNA levels. (F, G, H, I) GSEA enrichment of genes with significant changes in both the m6A modification and RNA levels.