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. 2022 Jun 30;10(7):1224. doi: 10.3390/healthcare10071224

Table 1.

Characteristic of included studies.

Authors, Year, Study Location Study Design Population Intervention Quality
Sample Size Mean/Range Age (Years) Psychosocial Condition Intervention Frequency Assessment Follow Up
Mahoney et al. (2021) [22] Australia RCT 5074
Female (3557)
Male (1311)
Unspecified (332)
37.31 (13.53) Adults experiencing symptoms of anxiety and depression THIS WAY UP (thiswayup.org.au) iCBT self-guided or guided by the end-user’s clinician, users granted 90 days access to complete their course Depression: PHQ 9
Anxiety: GAD-7
- 6/7 ***
Sharrock et al. (2021) [33] Australia RCT 778
Female (526)
Male (220)
Unspecified (332)
37.76 (12.64) Adults experiencing symptoms of anxiety and depression THIS WAY UP (thiswayup.org.au) iCBT Ninety days. There is a five-day wait-period between lessons two to six to give participants time to practice the skills covered in the lessons. Depression: PHQ-9
Anxiety: SHAI
- 6/7 ***
Ying et al. (2021) [36] China RCT 127
Female (87)
Male (40)
73.39 (7.37) Symptoms of depression, anxiety, general psychological distress, and functional disability Healthy Psychological Station (iCBT clinician guided) Post-treatment (5 weeks) Depression: PHQ-9
Anxiety: GAD-7
1 month 6/7 ***
Oehler et al. (2021) [37] Germany RCT 1423
Female (946)
Male (477)
40.15 (13.35) guided sample of patients with depression iFightDepression tool (iFD), a web-based CBT intervention at least two workshops in the first six weeks Depression: PHQ-9 - 7/7 ***
Aminof et al. (2021) [38] Swedia RCT 26
Female (19)
Male (7)
42.1 (16.8) Participant with elevated levels of psychological distress 7-week-long individually tailored ICBT Individual with 13 times completion module for 7 weeks Depression: PHQ-9
Anxiety: GAD-7
- 7/7 ***
Nordgreen et al. (2021) [39] Norway RCT 82
Female (65)
Male (17)
40 (14.19) Self-reported depressive and anxiety symptoms and change in positive and negative emotions. Self-guided Internet-delivered intervention integrated with The person-based approach (PBA; Yardley et al., 2015) a new module every third day (3- day group, a total of 28 days) or a new module every fifth day (5-day group, a total of 40 days). Depression: PHQ-9
Anxiety: GAD-7
6 weeks 5/7 ***
Wahlund et al. (2020) [40] Swedia RCT 335
Female (277)
Male (58)
45 (13) Daily uncontrollable worry about COVID-19 and its possible consequences (e.g., illness, death, the economy, one’s family) 3 weeks, Self-guided online cognitive behavioral intervention Self-guided module, tasks to practice during at least a couple of days for 3 weeks Anxiety: GAD-7 4 weeks 7/7 ***
Shapira et al. (2021) [41] Israel RCT 82
Female (66)
Male (16)
72 (5.6) community-dwelling older adults iCBT via Zoom online sessions via the Zoom video conferencing platform were delivered to groups of 5–7 people during seven sessions over 3.5 weeks each lasting between 1–1.5 h Depression: PHQ-9 1 month 7/7 ***
Perri et al. (2021) [42] Italy RCT 19
Female (13)
Male (6)
52.4 (10.6) subjects requiring psychological support to manage the ongoing trauma associated with quarantine, isolation or work in COVID-19 hospital wards trauma-focused cognitive-behavioral therapy (TF-CBT) using skype received a 7-session therapy for a total duration of about 3 weeks (2 sessions per week) Depression: BDI-II
Anxiety: STAI-Y1
1 month 6/7 ***
Bantjes et al. (2021) [43] South Africa RCT 158
Female (135)
Male (23)
22.4 (4.9) Web-based groups were being offered to help students learn psychological skills to reduce symptoms of anxiety and depression Web-based (Microsoft Teams) group cognitive behavioral therapy 10 weekly workshops of 60–75 min. Depression: PHQ 9
Anxiety: GAD-7
4 weeks 6/7 ***
Liu et al. (2021) [34] China RCT 326
Female (102)
Male(150)
IG: 43.76 (14.31)
CG: 41.52 (11.51)
COVID-19 patients had mild to moderate depression or anxiety symptoms. Computerized cognitive behavioral therapy (cCBT) 10 min per day to self-directed individual therapy for 1 week Depression: HAMDA-17
Anxiety: HAMA
4 weeks 7/7 ***
Al-Alawi et al. (2021) [35] Oman RCT 46
Female (36)
Male (10)
28.51 (8.70) People in the community with anxiety and depression iCBT 6 sessions of therapist-guided online or self-help therapy for week 6 Depression: PHQ-9
Anxiety: GAD-7
6 weeks 6/7 ***

Note. (***) Low; BDI = Back’s Depression Inventory; GAD = General Anxiety Disorder; iCBT = Internet-Based Cognitive Behavioral Therapy; HAMA = Hamilton Anxiety Scale; HAMDA = Hamilton Depression.