Table 2.

Study outcome.

Study	Sub Study	Efficacy							Adherence
		Pre			Post			p-Value
		Mean	SD	Total Patients	Mean	SD	Total Patients
Mahoney et al. (2021) [22]	Depression	14.11	6.13	5074	8.98	5.07	5074	<0.001	Clinician guided: 30.8% Self-guided: 20.1%
	Anxiety	11.79	5.20	5074	7.28	4.36	5074	<0.001
Sharrock et al. (2021) [33]	Depression	9.54	7.50	778	06.09	5.74	778	<0.001	Clinician guided: 31.43% Self-guided: 30.08%
	Anxiety	29.15	11.13	778	20.54	10.18	778	<0.001
Ying et al. (2021) [36]	Depression	10.57	1.42	127	6.46	2.57	127	<0.001	Clinician guided: 87.4%
	Anxiety	9.51	1.31	127	6.18	2.55	127	<0.001
Oehler et al. (2021) [37]	Depression	13.83	4.85	940	10.72	5.66	940	<0.001	Self-guided: 83,1%
Aminof et al. (2021) [38]	Depression	11.23	5.19	26	5.83	5.42	26	0.076	Clinician guided: 61.6%
	Anxiety	11.46	5.56	26	5.04	4.61	26	0.01
Nordgreen et al. (2021) [39]	Depression	9.23	04.07	82	7.54	5.34	82	<0.05	Self-guided: 61%
	Anxiety	9.40	4.17	82	6.63	5.25	82	<0.001
Wahlund et al. (2020) [40]	Anxiety	13.93	4.10	335	8.40	4.95	335	<0.001	Self-guided: 60%
Shapira et al. (2021) [41]	Depression	6.6	5.2	64	5.2	4.7	64	<0.05	Clinician guided: 74,4%
Perri et al. (2021) [42]	Depression	21.7	9.6	19	9.3	9.9	19	<0.0001	Clinician guided: 90.4%
	Anxiety	47.2	12.2	19	29.8	11.8	19	<0.0001
Bantjes et al. (2021) [43]	Depression	14.0	3.6	125	8.5	5.0	125	<0.001	Clinician guided: 71.4%
	Anxiety	14.1	3.5	125	6.9	4.2	125	<0.001
Liu et al. (2021) [34]	Depression	15.28	2.23	51	6.86	1.77	51	<0.001	N/I
	Anxiety	14.26	2.31	51	6.10	2.04	51	<0.001
Al-Alawi et al. (2021) [35]	Depression	N/I	N/I	22	N/I	N/I	22	0.06	N/I
	Anxiety	N/I	N/I	22	N/I	N/I	22	0.01