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In vivo doxorubicin release from IMP301 and DOXIL under FUS irradiation using IMD-10R. (a) System configuration of IMD-10R. (b) Schematic illustration of animal setting in water tank of IMD-10R. (c) The fluorescence intensity of doxorubicin was specifically detected using spectral unmixing at 408–460 nm excitation and emission for removal of autofluorescence after intravenous injection of DOXIL or IMP301 without or with FUS treatment.
