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. 2022 Jul 8;14(7):1436. doi: 10.3390/pharmaceutics14071436

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) Human skin explants with implanted OFM probes, O-shaped patches, and sampling vials. (B) Detailed setup of (1) FTSE with (2) an implanted OFM probe and (3) an O-shaped patch to avoid cross-contamination and define the size of the application area. (C) Setup of online monitoring (1) FTSE, (2) lead flow-through cell for oxygen and pH, (3) multi-analyte meter FireSting^®-PRO, (4) second flow-through cell for glucose and lactate, and (5) biosensor measuring instrumentation (Six, Jobst Technologies).