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Association of HSPG2 mutations with mutational burden in melanoma. (A) Distinct TMB distribution in HSPG2-mutated versus wild-type subgroups. (B) Multivariate logistic regression model of HSPG2 mutations was performed with clinical and genomic confounders taken into consideration. (C) Distinct NB distribution in HSPG2-mutated versus wild-type subgroups. Connection of HSPG2 mutations with (D) TMB and (E) NB based on the data from the TCGA melanoma cohort.
