Table 6.

Antibacterial activity of NO-releasing hydrogels against Gram-positive and Gram-negative bacteria, with a focus on the systems with enhanced wound healing tested in vivo. Methicillin-resistant S. aureus (MRSA) and multidrug-resistant P. aeruginosa (MRPA).

Gram +	Gram −	Effect	NO Donor/Hydrogel	References
Antibacterial activity assessed in vitro
S. aureus	E. coli	Bactericidal	Metal-NO complex/Chitosan, PVA	[90]
	E. coli	Bactericidal	Nitro compound/Poly(cyclodextrin)	[91]
S. epidermis	E. coli	Bactericidal	NONOate/Chitosan, Hyaluronic acid	[41]
S. mutans S. aureus	E. coli	Bactericidal	RSNO/Alginate	[112]
	P. aeruginosa	Bactericidal	GSNO/Chitosan, Pluronic F-127	[34]
S. aureus	P. aeruginosa	Bactericidal	NONOate/Alginate, PEI	[27]
	P. aeruginosa	Bactericidal Biofilm dispersal	NONOate/antimicrobial polymer	[87]
With enhanced wound healing tested in vivo
S. aureus	E. coli	Bactericidal	BNN6/GelMA	[42]
S. aureus	P. aeruginosa	Bactericidal	GSNO/Chitosan	[46]
MRSA	P. aeruginosa	Bactericidal	GSNO/Alginate, Pectin, PEG	[40]
MRSA	MRPA	Bactericidal	GSNO/Alginate	[110]