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. 2022 Jul 22;8(2):e002208. doi: 10.1136/rmdopen-2022-002208

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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(A) A total of 185 (74.9%) male and 62 (25.1%) female HlA-B27 positive probands with ankylosing spondylitis (AS) meeting the radiographic New York criteria for sacroiliitis participated in the follow-up study. Mothers with AS had 29 children and fathers with AS had 119 children. The figure shows that 12 of 29 (41.4%) children of HLA-B27 positive AS mothers versus 15 of 119 (12.6%) children of HLA-B27 positive AS fathers have axial spondyloarthritis (axSpA) at follow-up (p=0.00032, OR=4.89 with 95% CI 1.96 to 12.23). At follow-up, all children were ≥45 years of age. (B) A total of 269 of 360 (74.7%) probands with AS met the radiographic New York criteria for sacroiliitis, whereas 91 (25.3%) had non-radiographic axial spondyloarthritis (nr-axSpA). The bar graphs show that 27 of 148 (18.2%) children of AS parents (meeting the radiographic New York criteria) versus 2 of 50 (4.0%) children of parents with nr-axSpA (p=0.0138, OR=5.36 with 95% CI 1.23 to 23.40) develop axial SpA. All children were ≥45 years of age at follow-up.