Table 1.

Demographic and clinical characteristic for study participants

	M0		M12
	Edinburgh (n=98)	Glasgow (n=87)	Edinburgh (n=92)	Glasgow (n=63)
Age (years, mean±SD)	37.17±11.05	37.02±9.58	39.27±11.12	37.29±10.11
Gender (F:M)	75:23	59:28	67:25	43:20
Disease duration (days, mean±SD)	62.15±36.88	59.85±36.28
Visual symptom at onset (n / %)			N/A	N/A
Vision loss	25/58.14%	14/53.85%
Double vision	14/32.56%	10/38.46%
Both	4/9.30%	2/7.69%
EDSS score (median/IQR)	2/1.5	2/1	2.5/1.5	2.5/1
MSFC (median/IQR)	0.200/0.689	0.167/0.893	0.384/0.881	0.359/0.741
ON history (n / %)
No history of ON	54/60.67%*	39/68.42%†	47/58.75%‡	27/72.97%§
Unilateral ON	32/35.56%	13/22.81%	28/35%	8/21.62%
Bilateral ON	3/3.37%	3/8.77%	5/6.25%	3/5.41%

*Edinburgh site (M0): Total number of 89 participants have ON history available based on self-reported eye questionnaire and clinical records.

†Glasgow site (M0): Total number of 55 participants have ON history available based on self-reported eye questionnaire and clinical records.

‡Edinburgh site (M12): Total number of 80 participants have ON history available based on self-reported eye questionnaire and clinical records.

§Glasgow site (M12): Total number of 38 participants have ON history available based on self-reported eye questionnaire and clinical records.

EDSS, Expanding Disability Status Scale; MSFC, Multiple Sclerosis Functional Composite; ON, Optic Neuritis.