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. 2022 Jun 6;12(7):e056517. doi: 10.1136/bmjopen-2021-056517

Table 4.

Results of subgroup analysis of interventions on outcomes of water immersion for labour and waterbirth compared with standard care

Outcome Studies Sample Effect
OR (95% CI) model
Heterogeneity
Q (p) I2%
Labour Induction*
 Obstetric units 2 604 Immersion
792 Standard care
0.32 (0.06 to 1.58)
Random effects
18 (<0.01)
94
Amniotomy*
 Obstetric units 4 306 Immersion
709 Standard care
0.95 (0.62 to 1.46)
Random effects
5 (0.17)
40
 2010 and earlier 3 192 Immersion
250 Standard care
0.87 (0.46 to 1.64)
Random effects
4 (0.13)
51
 2011 and later 2 420 Immersion
765 Standard care
0.56 (0.15 to 2.02)
Random effects
14 (<0.01)
93
Augmentation*
 Obstetric units 2 203 Immersion
605 Standard care
0.48 (0.16 to 1.51)
Random effects
6 (0.02)
83
 2011 and later 2 420 Immersion
765 Standard care
0.32 (0.05 to 2.24)
Random effects
19 (<0.01)
95
Opioid use
 2010 and earlier 6 4298 Immersion
6565 Standard care
0.23 (0.08 to 0.70)
Random effects
95 (<0.01)
95
 2011 and later 2 1641 Immersion
14 887 Standard care
0.17 (0.15 to 0.20)
Fixed effects
0 (0.54)
0
Epidural*
 Obstetric units 6 4104 Immersion
6889 Standard care
0.26 (0.08 to 0.83)
Random effects
89 (<0.01)
94
 2010 and earlier 6 4104 Immersion
6889 Standard care
0.26 (0.08 to 0.83)
Random effects
89 (<0.01)
94
Pain
 2010 and earlier 3 182 Immersion
188 Standard care
0.53 (0.27 to 1.03)
Random effects
6 (0.05)
68
 2011 and later 5 417 Immersion
413 Standard care
0.15 (0.06 to 0.42)
Random effects
48 (<0.01)
92
Caesarean delivery
 2010 and earlier 4 790 Immersion
745 Standard care
1.05 (0.63 to 1.74)
Fixed effects
3 (0.43)
0
 2011 and later 4 400 Immersion
830 Standard care
0.84 (0.32 to 2.23)
Fixed effects
6 (0.12)
48
Shoulder dystocia
 Obstetric units 6 5528 Immersion
21 155 Standard care
1.06 (0.64 to 1.74)
Fixed effects
4 (0.60)
0
 2010 and earlier 3 4007 Immersion
6335 Standard care
0.88 (0.42 to 1.83)
Fixed effects
2 (0.39)
0
 2011 and later 4 11 773 Immersion
31 252 Standard care
0.87 (0.33 to 2.26)
Random effects
11 (0.01)
73
Intact perineum
 Obstetric units 14 6170 Immersion
8866 Standard care
1.55 (1.12 to 2.16)
Random effects
147 (<0.01)
91
 Midwifery-led units 3 17 079 Immersion
23 249 Standard care
1.07 (0.91 to 1.26)
Random effects
15 (<0.01)
87
 Nulliparas 5 1065 Immersion
894 Standard care
1.59 (1.01 to 2.50)
Random effects
12 (0.01)
68
 Waterbirth versus no water 8 954 Immersion
1696 Standard care
1.35 (0.67 to 2.72)
Random effects
83 (<0.01)
92
 2010 and earlier 7 4958 Immersion
6949 Standard care
1.28 (0.90 to 1.82)
Random effects
39 (<0.01)
85
 2011 and later 10 18 292 Immersion
28 871 Standard care
1.59 (1.22 to 2.07)
Random effects
156 (<0.01)
94
OASI
 Obstetric units 13 10 720 Immersion
57 870 Standard care
0.85 (0.57 to 1.30)
Random effects
51 (<0.001)
77
 Midwifery-led units 2 6827 Immersion
10 558 Standard care
0.71 (0.47 to 1.08)
Fixed effects
0 (0.527)
0
 Nulliparas 2 870 Immersion
540 Standard care
1.25 (0.42 to 3.71)
Fixed effects
1 (0.385)
0
 Waterbirth versus no water 3 408 Immersion
550 Standard care
0.57 (0.19 to 1.69)
Fixed effects
1 (0.681)
0
 2010 and earlier 6 5493 Immersion
7517 Standard care
0.73 (0.58 to 0.91)
Fixed effects
8 (0.16)
37
 2011 and later 9 13 298 Immersion
67 382 Standard care
0.78 (0.48 to 1.28)
Random effects
42 (<0.01)
81
Episiotomy*
 Obstetric units 14 6177 Immersion
13 548 Standard care
0.17 (0.11 to 0.28)
Random effects
109 (<0.001)
88
 Nulliparas 3 886 Immersion
582 Standard care
0.10 (0.02 to 0.60)
Random effects
14 (<0.001)
86
 Waterbirth versus no water 5 691 Immersion
1022 Standard care
0.63 (0.02 to 0.20)
Random effects
14 (0.008)
71%
 2010 and earlier 7 4927 Immersion
6912 Standard care
0.21 (0.11 to 0.41)
Random effects
52 (<0.01)
88
 2011 and later 8 7831 Immersion
16 888 Standard care
0.09 (0.03 to 0.25)
Random effects
53 (<0.01)
87
Postpartum faemorrhage
 Obstetric units 13 7040 Immersion
29 555 Standard care
0.75 (0.60 to 0.94)
Random effects
30 (0.002)
60
 Midwifery-led units 2 10 558 Immersion
16 738 Standard care
0.39 (0.08 to 1.86)
Random effects
56 (<0.001)
98
 Waterbirth versus no mater 5 758 Immersion
1177 Standard care
1.02 (0.76 to 1.36)
Fixed effects
4 (0.439
0
 2010 and earlier 3 4007 Immersion
6348 Standard care
0.72 (0.59 to 0.88)
Random effects
2 (0.30)
17
 2011 and later 12 13 591 Immersion
39 945 Standard care
0.76 (0.48 to 1.20)
Random effects
97 (<0.01)
89
Manual removal of placenta
 Obstetric units 4 1239 Immersion
1654 Standard care
0.78 (0.37 to 1.64)
Fixed effects
6 (0.105)
51
 2010 and earlier 2 701 Immersion
771 Standard care
0.48 (0.21 to 1.11)
Fixed effects
0 (0.91)
0
 2011 and later 3 538 Immersion
883 Standard care
1.48 (0.50 to 4.38)
Fixed effects
4 (0.16)
45
Maternal satisfaction
 Obstetric units 5 1802 Immersion
1568 Standard care
2.02 (1.28 to 3.19)
Random effects
24 (<0.01)
83
 2010 and earlier 4 1815 Immersion
1519 Standard care
1.64 (0.83 to 3.24)
Random effects
22 (<0.01)
86
 2011 and later 2 372 Immersion
438 Standard care
2.55 (1.54 to 4.23)
Random effects
2 (0.16)
50
APGAR
 Obstetric units 18 10 286 Immersion
54 361 Standard care
0.85 (0.66 to 1.08)
Random effects
29 (0.047)
38
 Midwifery-led units 3 17 092 Immersion
18,31 Standard care
0.33 (0.07 to 1.54)
Random effects
57 (<0.001)
96
 Waterbirth versus no water 6 614 Immersion
655 Standard care
1.07 (0.76 to 1.51)
Fixed effects
3 (0.643)
0
 2010 and earlier 8 4184 Immersion
6476 Standard care
1.00 (0.77 to 1.29)
Fixed effects
7 (0.120)
39
 2011 and later 12 21 931 Immersion
65 781 Standard care
0.52 (0.25 to 1.05)
Random effects
101 (<0.001)
89
Neonatal death
 Midwifery-led units 2 16 786 Immersion
26 722 Standard care
0.91 (0.61 to 1.34)
Fixed effects
1 (0.297)
8
Cord avulsion
 Obstetric units 3 1874 Immersion
21 621 Standard care
2.18 (0.34 to 11.97)
Fixed effects
1 (0.757)
0
 Midwifery-led units 2 10 649 Immersion
16 829 Standard care
1.92 (1.28 to 2.89)
Fixed effects
1 (0.386)
0

*Random effects models were used for intervention (labour induction, amniotomy, augmentation, epidural, and episiotomy) models because variation in use of these procedures is dependent on practice habits of the provider which are not otherwise controlled.

OASI, obstetric anal sphincter injury.