Table 2.

The results of univariate and multivariate Cox regression analyses on variables for the prediction of CSS of advanced hepatocellular carcinoma patients.

Variable	Univariate		P value	Multivariate		P value
	HR	95% CI		HR	95% CI
Age
<65	Reference			Reference
>65	1.1	1.00–1.20	0.03	1.17	1.01–1.22	0.02
Race
Black	Reference			Reference
White	1.02	0.90–1.15	0.71	1.08	0.96–1.22	0.18
Other	1.09	0.95–1.26	0.19	1.25	1.07–1.45	<0.001
Sex
F	Reference			Reference
M	1.12	0.99–1.24	0.06	1.06	0.96–1.19	0.26
AJCC Stages a
III	Reference			Reference
IV	1.52	0.39–1.66	<0.001	1.5	1.2–1.89	<0.001
Tumor size
0–5	Reference			Reference
5–10	0.84	0.77–0.92	<0.05	0.93	0.85–1.03	0.19
>10	1.21	0.82–0.98	0.07	1.18	0.94–1.46	0.13
Number
1	Reference			Reference
>1	0.82	0.72–0.93	<0.001	0.84	0.74–0.96	0.01
Regional nodes
Negative	Reference			Reference
Not examined	2.08	1.67–2.60	<0.001	1.28	1.01–1.62	0.03
Positive	1.22	1.09–1.36	<0.001	1.12	0.94–1.33	0.17
Treatment
No operation	Reference			Reference
Local tumor destruction	0.47	0.36–0.62	<0.001	0.37	0.28–0.49	<0.001
Hepatectomy or transplant	0.31	0.25–0.38	<0.001	0.22	0.18–0.28	<0.001
Radiation
Yes	Reference			Reference
No	1.5	1.33–1.69	<0.001	1.93	1.70–2.10	<0.001
Chemotherapy
Yes	Reference			Reference
No	1.87	1.69–2.01	<0.001	2.29	2.09–2.51	<0.001
DX bone b
Yes	Reference			Reference
No	0.7	0.61–0.80	<0.001	0.78	0.66–0.93	<0.001
DX lung
Yes	Reference			Reference
No	0.57	0.50–0.65	<0.001	0.82	0.70–0.96	<0.001
Marital
Married	Reference			Reference
Divorced	1.26	1.13–1.40	<0.001	1.14	1.02–1.28	0.01
Single	1.23	1.14–1.36	<0.001	1.17	1.05–1.30	<0.001

^aAJCC Stages: The seventh edition American Joint Committee on Cancer (AJCC) TNM staging system.

^bDX, distant metastasis.