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. 2022 Jul 20;14(14):2963. doi: 10.3390/nu14142963

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Results of the components-targets analysis conducted via the platform STITCH. The results suggested the capability of citicoline to interact with monoamine oxidase A (MAO-A). Additionally, citicoline was predicted to modulate dopamine uptake, through interaction with the neurotransmitter carrier (SLC22A2), and through phosphatidylcholine synthesis, in which it interacts with phosphate cytidylyltransferases (PCYT1B and PCYT1A). On the other hand, CAVAQ10 was predicted to interact with cytochrome b (MT-CYB), involved in the ATP biosynthesis, and fibroblast growth factor-2 (FGF2).