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(a) Reactome, PID, WP, and BioCarta database analysis. (b) GSEA analysis. (c) Determination of NAD/NADH ratio in U251 andU87 glioma cells using ELISA. (d) Analysis results of the effect of SIRT1 knockdown by Western blot. (e) Correlation analysis between SIRT1 and NNMT. Values are expressed as means ± SEM, * p < 0.05, compared with DOX 0.
