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. Author manuscript; available in PMC: 2022 Jul 26.
Published in final edited form as: Nature. 2021 Sep 22;597(7878):693–697. doi: 10.1038/s41586-021-03933-1

Figure 2: Remodeling of interneuron chromatin architecture during migration and post-settling.

Figure 2:

a,b,c,d UMAP of coembedded scRNA- and scATAC-seq data (top) and prediction scores of scATAC-seq assignment to scRNA-defined clusters (bottom) at E18 (a), P2 (b), P10 (c), P28 (d).

e, Jaccard distance analysis for PV and SST cell scATAC-seq peaks across timepoints.

f, Average signal within cell type-specific accessible peaks identified at P28 located for proximal elements (gene bodies or promoters: TSS+/−2kb) or distal elements across timepoints.

g, Aggregated scores (AS) for branch-specific peaks.

h, Motif enrichment (ME) in class-specific loci at each timepoint. Each TF enrichment value is normalized by the largest enrichment value in the population.

i, Relative distribution of P28 MEF2C CUT&RUN peaks in PV versus SST interneurons.

j, Peaks identified exclusively in CUT&RUN (orange) or jointly in CUT&RUN and ATAC-seq analyses (green).

k, Number of genes linked to CUT&RUN peaks found uniquely in PV (blue), SST (red) or shared in both populations (purple). Peaks were assigned to genes based on scATAC co-accessibility with promoters.

SPMR, signal per million reads; ME, Motif Enrichment; AS, Aggregated Score; C&R, CUT&RUN