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. Author manuscript; available in PMC: 2022 Jul 26.
Published in final edited form as: Nature. 2021 Sep 22;597(7878):693–697. doi: 10.1038/s41586-021-03933-1

Extended Data Figure 2. Developmental characterization of embryonic E13 MGE cells surveyed using scRNA-seq, scATAC-seq, and multiomic methods.

Extended Data Figure 2.

a, Analysis of Dlx6a−, Dlx6a+ and multiome scRNA-seq datasets collected from E13 MGE in Dlx6a-Cre;Ai9 mice and multiome dataset in E13 MGE wild type mice.

b, Analysis of Dlx6a−, Dlx6a+ and multiome scATAC-seq datasets collected from E13 MGE in Dlx6a-Cre;Ai9 mice and multiome dataset in E13 MGE wild type mice.

i, Dlx6+/− FAC-sorted and multiome cells.

ii, Unbiased cluster annotation.

iii, Dlx6+ and Dlx6- annotation.

iv, Cell cycling phase annotation.

v, Pseudotime annotation.

vi, Mitotic and postmitotic cell annotation.

In ii-vi, Annotations are performed on scRNA-seq datasets and transferred to scATAC-seq datasets through the multiome dataset. scRNA- and scATAC-seq low dimensional representation reflects UMAP embedding.

vii, Average gene expression and promoter accessibility for unbiased clusters.