Table 1.
Clinical characteristics of studies analyzing choroidal thickness and vascularity alterations in patients with Stargardt disease.
| Study | Study Design | Number of Patients (Number of Eyes) with Stargardt Disease/Controls | CT Alterations | CVI Alterations | Correlations between CT and BCVA |
|---|---|---|---|---|---|
| Yeoh et al., 2010 [35] | Prospective observational case series | Cases: 5 | 2 pts: no 3 pts: choroid thinning |
- | No association between choroidal thinning and visual acuity |
| Sabbaghi et al., 2020 [33] | Comparative study | Cases: 38 (76) Controls: 56 (109) |
No differences in mean total and SFCT | - | Inverse correlation of SFCT with BCVA |
| Ratra, Tan et al., 2018 [7] | Retrospective cohort study | Cases: 39 Controls: 25 |
No differences in SFCT | Decreased CVI in patients with Stargardt disease |
Negative association between visual acuity and CVI Positive association between visual acuity and SFCT |
| Chhabblani et al., 2015 [32] | Retrospective study | Cases: 9 (18) | No choroidal thinning | - | No significant correlation between subfoveal CT and BCVA |
| Adhi et al., 2015 [28] | Cross-sectional retrospective review | Cases: 28 (53) Controls: 30 (30) |
No differences in mean total and SFCT | - | No correlation between CT and BCVA |
| Ratra, Jaishankar et al., 2018 [30] | Case-control study | Cases: 26 (52) Controls: 26 (52) |
Total CT decreased in cases | - | No correlation between CT and BCVA BCVA worsened with increasing lesion size and wider extent of flecks |
BCVA: best corrected visual acuity; CT: choroidal thickness; CVI: choroidal vascularity index; SFCT: subfoveal choroidal thickness.