Figure 3.

Evolution of wild-type- and SARS-CoV-2 variant-neutralizing capacities in vaccinated-LTRs. Data are expressed in log₁₀. (a) Dilution titers of anti-SARS-CoV-2 IgG at day 0 (n = 49), 28 (n = 47), 84 (n = 49), 112 (n = 44), 180 (n = 42), 210 (n = 32), and 238 (n = 28), assessed by pseudovirus neutralization test (pVNT) (geometric mean ± 95% CI). Statistical analysis by Kruskal–Wallis test followed by a post hoc Dunn’s test provided non-significant results. (b) Paired Delta and Omicron SARS-CoV-2 neutralizing capacities of wild-type-positive samples (n = 45) assessed by pVNT (geometric mean ± 95% CI). Dotted black lines represent the positivity cut-offs for neutralization (>20 dilution titer, i.e., 1.3 in log₁₀). *** p < 0.001 wild-type vs. Delta and Omicron by the Kruskal–Wallis test followed by a post hoc Dunn’s test. D1 and D2 correspond to the first and second doses of ChAdOx1, respectively; B corresponds to the booster dose, BNT162b2.