Table 2.
The median lethal dose (LD50) data of Andrographis paniculata extract and its constituents.
| Substance | Route/Model * | LD50 Value (g/kg Bodyweight) |
Reference |
|---|---|---|---|
| 14-deoxy-11,12-didehydroandrographolide | oral/mice | >20 | [175] |
| A. paniculata alcoholic extract | N/A | 1.8 | [176] |
| A. paniculata ethanolic extract (first true leaf) | oral/mice | >5 | [174] |
| A. paniculata extract | N/A | >17 | [177] |
| Andrographolide | oral/mice | >5 | [173] |
| Andrographolide | ip/mice | 11.46 | [178] |
| Andrographolide | oral/mice | >40 | [175] |
| Deoxyandrographolide | oral/mice | >20 | [175] |
| Neoandrographolide | oral/mice | >20 | [175] |
| Total diterpene lactone | oral/mice | 13.4 | [175] |
* ip: intraperitonial injection, N/A: not available.