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. 2022 Jun 29;14(7):1380. doi: 10.3390/pharmaceutics14071380

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© 2022 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of miR-122 on the epigenetic regulation of cancer cells. H3K9 methylation by G9a reduces the expression of the proapoptotic regulators Bcl-G, MAP1LC3B, and RARRES3 in hepatocellular carcinoma (HCC) (upper). H3K56 deacetylation by SIRT6 is involved in DNA repair, genome maintenance, and cell survival leading to carcinogenesis (lower). miR-122 suppresses the progression of HCC by directly downregulating G9a and SIRT6. SIRT6 and miR-122 reciprocally regulate each other via a negative feedback mechanism.