Skip to main content
. 2022 Jun 29;14(7):1380. doi: 10.3390/pharmaceutics14071380

Figure 6.

Figure 6

Regulation of glucose metabolism by miR-122 in hepatocellular carcinoma. miR-122 targets ALDOA and PKM2 in the glycolysis pathway. ALDOA is one of the key regulators in hepatocellular carcinoma (HCC) development, wherein its levels increase under hypoxic conditions in HCC cells. PKM2 is responsible for aerobic glycolysis, which is a prominent characteristic of cancer cells. PPP is activated in cancer cells, and G6PC is the enzyme that catalyzes the rate-determining step in the activation of PPP. CS catalyzes the biosynthesis of citrate, which is a key enzyme in fatty acid synthesis in HCC. G6PC3 is one of the isotypes of G6P that produces glucose from glucose 6-phosphate in the gluconeogenesis pathway. GYS1 mediates the synthesis of glycogen. Although G6PC3 and GYS1 are direct targets of miR-122 in HCC, the functional link of these enzymes to HCC is not clear yet.