. 2022 Jun 29;14(7):1374. doi: 10.3390/pharmaceutics14071374

Table 2.

The outcomes of all statistical analyses of response variables.

Source	PS		ZP		EE
Source	F-Value	p-Value	F-Value	p-Value	F	p-Value
Model	205.09	<0.0001	152.80	<0.0001	104.05	<0.0001
X₁: GMO (w/v %)	746.25	<0.0001	439.97	<0.0001	64.53	<0.0001
X₂: P 407 (w/w %)	6.73	0.0267	14.77	0.0027	473.33	<0.0001
X₃: T 80 (w/w %)	8.50	0.0154	3.67	0.0818	4.41	0.0689
X₁ X₂					12.10	0.0083
X₂²	58.87	<0.0001			67.71	<0.0001
X₃²					4.29	0.0720
Lack of Fit	1.45	0.4703	5.36	0.1670	7.02	0.1298
Model	Reduced Quadratic		Linear		Reduced Quadratic
Adjusted R²	0.9831		0.9702		0.9779
R²	0.9880		0.9766		0.9873
%CV	1.85		2.20		10.48
Predicted R²	0.9730		0.9508		0.9416
Adequate precision	43.7095		33.9851		30.8347
Standard deviation	0.0012		0.0008		14,008.91
$1 / Sqrt (PS) = 0.066 - 0.011 \cdot X_{1} + 0.0012 \cdot X_{2} - 0.0013 \cdot X_{3} - 0.005 \cdot X_{2}^{2}$
$1 / (ZP) = 0.034 - 0.006 \cdot X_{1} + 0.001 \cdot X_{2} + 0.0005 \cdot X_{3}$
${(E E)}^{3} = 93,786.5 - 39,786.5 \cdot X_{1} + 107,756 \cdot X_{2} + 10,400.6 \cdot X_{3} - 24,369.2 \cdot X_{1} \cdot X_{2} + 59,813.4 \cdot X_{2}^{2} + 15,60.6 \cdot X_{3}^{2}$