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. 2022 Jun 24;14(7):1336. doi: 10.3390/pharmaceutics14071336

Table 2.

BBD parameters with experimental and actual values for the nanoemulsions involving PC essential oil.

Experimental Run Coded of Independent Factors Observed Values Predicted Values
(S1) (S2) (S3) PS (nm) PDI PS (nm) PDI
1 −1 −1 0 232.65 ± 11.9 0.169 ± 0.01 202.26 0.180
2 1 −1 0 9.93 ± 0.33 0.067 ± 0.0007 4.82 0.082
3 −1 1 0 115.96 ± 0.93 0.134 ± 0.017 121.08 0.119
4 1 1 0 235.61 ± 4.11 0.168 ± 0.012 263.04 0.158
5 −1 0 −1 235.85 ± 2.43 0.70 ± 0.011 258.27 0.163
6 1 0 −1 121.7 ± 1.6 0.048 ± 0.0002 122.04 0.038
7 −1 0 1 9.95 ± 0.52 0.069 ± 0.0003 9.56 0.077
8 1 0 1 117.16 ± 2.51 0.136 ± 0.02 90.34 0.141
9 0 −1 −1 158.1 ± 2.77 0.126 ± 0.005 162.87 0.122
10 0 1 −1 411.9 ± 15.1 0.005 ± 0.0002 381.16 0.0264
11 0 −1 1 122.6 ± 0.83 0.046 ± 0.0001 152.44 0.027
12 0 1 1 116.1 ± 1.34 0.145 ± 0.023 111.20 0.139
13 0 0 0 189 ± 4.57 0.168 ± 0.005 207.84 0.174
14 0 0 0 201.86 ± 3.75 0.186 ± 0.02 207.84 0.174
15 0 0 0 233.46 ± 5.87 0.166 ± 0.03 207.84 0.174

S1 = coded value of Tw80 (%), S2 = coded value of PC-EO (%), and S3 = coded value of water (%).