Table 2.
Study medication titration schedule
| Step 1 titration | Step 2 titration | Step 3 titration | |
|---|---|---|---|
| (verinurad/allopurinol) | (verinurad/allopurinol) | (verinurad/allopurinol) | |
| High dose, mg | 3/100 | 7.5/200 | 12/300 |
| Intermediate dose, mg | 3/100 | 7.5/200 | 7.5/300 |
| Low dose, mg | 3/100 | 3/200 | 3/300a |
| Allopurinol alone, mg | 0/100 | 0/200 | 0/300 |
| Placebo, mg | 0/0 | 0/0 | 0/0 |
a
Following Visit 9 (9 months after the end of the titration period), approximately half of patients in the verinurad 3 mg + allopurinol 300 mg/day arm will transition to verinurad 24 mg + allopurinol 300 mg/day to assess the safety and efficacy of verinurad at a higher dose.