Table 2.

Intestinal phenotypes of keratin-related mouse models.

Mouse Line	Intestinal Phenotype	Ref.
K7−/−	No disease phenotype on colon tissue histology	[45]
K8−/−	Residual K18 and K19 aggregates in proximity of cell surface in small and large intestine	[43]
	Colorectal hyperplasia, spontaneous Th2-type colitis	[43,44]
	Predisposition to colorectal cancer	[20,34]
K18 R89C	Minimal disruption of keratin filament in colon under basal condition, no effect on tissue histology	[47]
K20 R80H	Disrupted keratin filament in small intestinal villus under basal condition, no obvious effect on tissue histology	[11]