Figure 10.

Schematic diagram showing the proposed roles of hsa-miR-143-3p in the regulation of tau phosphorylation and Aβ production through DAPK1 in AD. (A) In healthy neurons, hsa-miR-143-3p reduces the expression of DAPK1 by directly binding to its mRNA 3′UTR, which results in inhibition of tau phosphorylation and Aβ production. (B) In AD neurons, the hsa-miR-143-3p levels are downregulated, and DAPK1 expression is upregulated, resulting in increased tau phosphorylation, APP phosphorylation, and Aβ secretion.