Table 5.
Qualitative synthesis showing the strong microbial taxonomic associations with CRC and the geographic origin of the populations in the studies.
| Microbial Taxa | CRC vs. HC N (%) Studies * |
Origin | CRC vs. NCT N (%) Studies ** |
Origin | |||
|---|---|---|---|---|---|---|---|
| E | W | E | W | ||||
| Phylum | Actinobacteria | 4 (14%) | 3 | 1 | |||
| Bacteroidetes | 5 (17%) | 1 | 4 | ||||
| Fusobacteria | 4 (40%) | 2 | 2 | 8 (28%) | 3 | 5 | |
| Family | Fusobacteriaceae | 3 (10%) | 2 | 1 | |||
| Porphyromonadaceae | 4 (14%) | 2 | 2 | ||||
| Rikenellaceae | 4 (14%) | 2 | 2 | ||||
| Ruminococcaceae | 7 (24%) | 5 | 2 | ||||
| Genus | Acinetobacter | 3 (10%) | 2 | 1 | |||
| Akkermansia | 3 (10%) | 2 | 1 | ||||
| Bacillus | 3 (10%) | 3 | 0 | ||||
| Bifidobacterium | 3 (10%) | 3 | 0 | ||||
| Blautia | 3 (30%) | 2 | 1 | 4 (14%) | 1 | 3 | |
| Campylobacter | 4 (40%) | 3 | 1 | 9 (31%) | 5 | 4 | |
| Collinsella | 3 (10%) | 3 | 0 | ||||
| Faecalibacterium | 5 (17%) | 3 | 2 | ||||
| Fusobacterium | 6 (60%) | 4 | 2 | 19 (66%) | 10 | 9 | |
| Gemella | 3 (10%) | 2 | 1 | ||||
| Granulicatella | 3 (30%) | 2 | 1 | 3 (10%) | 2 | 1 | |
| Klebsiella | 3 (30%) | 1 | 2 | ||||
| Parabacteroides | 9 (31%) | 5 | 4 | ||||
| Parvimonas | 4 (40%) | 3 | 1 | 8 (28%) | 6 | 2 | |
| Peptostreptococcus | 5 (50%) | 4 | 1 | 6 (21%) | 5 | 1 | |
| Propionibacterium | 3 (30%) | 2 | 1 | ||||
| Pseudomonas | 5 (17%) | 4 | 1 | ||||
| Ruminococcus | 6 (21%) | 3 | 3 | ||||
| Selenomonas | 4 (14%) | 4 | 0 | ||||
| Streptococcus | 3 (30%) | 2 | 1 | 7 (24%) | 4 | 3 | |
| Species | Bacteroides fragilis | 4 (40%) | 2 | 2 | 3 (10%) | 2 | 1 |
| Faecalibacterium prausnitzii | 3 (10%) | 0 | 3 | ||||
| Fusobacterium nucleatum | 3 (10%) | 1 | 2 | ||||
* [33,35,36,57,58,59,60,61,65,68]; ** [37,39,40,41,42,43,44,45,46,48,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,70]; E, Eastern origin; W, Western origin; Cells in magenta represent strong positive associations (≥3 studies in same direction; none in opposite direction); Cells in blue represent strong negative associations (≥3 studies in same direction; none in opposite direction).