Table 2.

Antiviral enzyme inhibitors and the antiviral mechanisms/targets.

Antiviral Drugs	Mechanisms/Targets	Virus	IC50/EC50 Value	Reference
Paxlovid	3CLpro and CYP3A4	SARS-CoV-2, HIV-1	-	[39,40]
3-(aminocarbonyl)-1-phenylpyridinium; 2,3-dichloroaphthoquinone	Mpro (Cys144, Glu165, Gln191)	PEDV, FIPV	EC50 = 100 μM	[42]
Hexachlorophenol	Mpro and ATPase	SARS-CoV	-	[43]
Xanthohumol	Mpro	BVDV, HSV-1, HSV-2, RhV, PEDV, SARS-CoV-2	IC50 = 1.53 µM and 7.51 µM	[44,45,46,47]
Tomatidine	3CLpro	PEDV, TGEV, PRRSV, EMCV, SVA, PEDV	-	[51]