8,14-DihydroxyEFV effect on performance of 5XFAD mice in behavioral tasks: (A), Barnes Maze test; (B), Y-maze test; and (C), fear conditioning tests. Data represent the mean ± SEM of the measurements in individual mice (17 control female mice, 15 treated female mice, 16 control male mice, and 17 treated male mice). Statistical significance was assessed by two-way repeated measures ANOVA with Bonferroni correction (the Barnes Maze test) and a two-tailed unpaired Student’s t-test (the Y-maze test and fear conditioning tests). * p = 0.03 was only detected between the session number and treatment factor in the Barnes maze test for male mice. Cntr, control mice; Tx, treated mice.