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CYP46A1 activation in vitro in the presence of different compounds. CYP46A1 activity is presented as nanomoles of 24-hydoxycholsterol (24HC) formed per nmole of CYP46A1 per min. The results are the mean ± SD of the measurements from the three independent experiments. *** p ≤ 0.001 as assessed by a two-tailed unpaired Student’s t-test. 8,14-diOH EFV, 8,14-dihydroxyEFV.
