Table 2.

The absorption, distribution, metabolism, excretion, and toxicity of the DB07639 and DB08432.

Title	Normal Values	DB07639	DB08432	Title	Normal Values	DB07639	DB08432
#acid	0–1	0	2	IP(eV)	7.9–10.5	0	0
#amide	0–1	0	0	Jm	N/A	0	0.003
#amidine	0	0	0	mol MW	130.0–725.0	433.549	338.271
#amine	0–1	3	0	% HumanOralAbsorption	>80% is high, <25% is poor	50.112	42.465
#in34	N/A	0	0	PISA	0.0–450.0	260.165	29.219
#in56	N/A	21	11	PSA	7.0–200.0	108.278	153.962
#metab	1–8	7	3	QPlogBB	−3.0–1.2	−1.188	−1.776
#NandO	2–15	6	9	QPlogHERG	concern below −5	−8.495	−0.274
#noncon	N/A	4	4	QPlogKhsa	−1.5–1.5	0.55	−0.909
#nonHatm	N/A	32	21	QPlogKp	−8.0–−1.0	−7.049	−5.278
#ringatoms	N/A	21	11	QPlogPC16	4.0–18.0	15.966	10.053
#rotor	0–15	10	6	QPlogPo/w	−2.0–6.5	2.434	1.062
#rtvFG	0–2	1	1	QPlogPoct	8.0–35.0	26.265	20.346
#stars	0–5	0	0	QPlogPw	4.0–45.0	15.875	15.661
accptHB	2.0–20.0	6.25	8.4	QPlogS	−6.5–0.5	−2.394	−2.741
ACxDN^.5/SA	0.0–0.05	0.0176843	0.0317999	QPPCaco	<25 poor, >500 great	3.15	3.31
CIQPlogS	−6.5–0.5	−2.997	−3.155	QPPMDCK	<25 poor, >500 great	1.324	4.15
CNS	−2 (inactive), +2 (active)	−2	−2	QPpolrz	13.0–70.0	47.608	26.903
dip^2/V	0.0–0.13	0	0	RuleOfFive	maximum is 4	0	0
dipole	1.0–12.5	0	0	RuleOfThree	maximum is 3	2	1
donorHB	0.0–6.0	5	4	SAamideO	0.0–35.0	0	0
EA(eV)	−0.9–1.7	0	0	SAfluorine	0.0–100.0	0	0
FISA	7.0–330.0	178.038	240.775	SASA	300.0–1000.0	790.275	528.304
FOSA	0.0–750.0	352.072	186.095	volume	500.0–2000.0	1441.735	915.318
glob	0.75–0.95	0.7809869	0.8629708	WPSA	0.0–175.0	0	72.214
HumanOralAbsorption	N/A	2	2