Skip to main content
. 2022 Jul 8;23(14):7571. doi: 10.3390/ijms23147571

Table 1.

Summary of writer and reader proteins for common mRNA modifications and the effects of these modifications on cellular RNA.

Modification Writers Readers Roles on RNA Refs
m6A METTL3,
METTL14,
METTL16		 YTHDF1-3,
YTDHC1-2,
HNRNPA2B1, HNRNPC, HNRNPG,
IGF2BPs,
eIF3,
FMRP,
LRPPRC		 Splicing, Stability, Structure, Translation, Export [19,23,25,33,39]
m1A TRMT6/61A,
TRMT61B,
TRMT10C		 YTHDF1-3,
YTHDC1		 Translation [30,43,44,45,46,47,48,49,50,51]
m5C NSUN,
DNMT2,
TRDMT		 ALYREF,
YBX1		 Structure,
Translation		 [52,53,54,55,56]
m7G METTL1/WDR4,
Trm8/Trm82		 Unknown Splicing, Stability,
Translation,
Export		 [57,58,59]
m6Am PCIF1 Unknown Regulating gene expression [60,61,62]
Ψ DCK1,
PUS1-10		 Unknown Splicing,
Stability,		 [63,64,65,66,67,68]
Nm FTSJ1 Unknown Stability,
Biogenesis, Metabolism, Function		 [69,70,71,72,73,74,75,76,77]
ac4C NAT10 Unknown Stability,
Translation,		 [78,79,80,81,82]