Table 1.
Correlation (Spearman coefficient, r) between protein and mRNA level of the ABC and SLC transporters in HCV cirrhotic livers (HCV) and disease stages (Child–Pugh class A, B, and C), as well as in the control.
| Gene/Protein | Control n = 20 |
HCV n = 58 |
Child–Pugh Class A n = 30 |
Child–Pugh Class B n = 21 |
Child–Pugh Class C n = 7 |
|---|---|---|---|---|---|
| ABCB1/P-gp | 0.432 | −0.251 | −0.174 | −0.270 | −0.393 |
| ABCC1/MRP1 | −0.481 * | 0.168 | 0.157 | 0.291 | −0.079 |
| ABCC2/MRP2 | 0.206 | 0.375 ** | 0.326 | 0.331 | 0.607 |
| ABCC3/MRP3 | 0.029 | 0.264 * | 0.304 | 0.092 | 0.571 |
| ABCC4/MRP4 | −0.220 | 0.304 * | 0.430 * | 0.041 | −0.185 |
| ABCG2/BCRP | LLOQ | −0.322* | 0.012 | −0.578 ** | −0.811 * |
| ABCB11/BSEP | 0.021 | 0.011 | 0.063 | −0.069 | 0.197 |
| SLC10A1/NTCP | 0.066 | 0.268 * | 0.189 | 0.357 | 0.321 |
| SLC22A1/OCT1 | 0.424 | 0.265 * | 0.195 | 0.104 | 0.714 |
| SLC22A3/OCT3 | 0.296 | −0.228 | −0.289 | −0.281 | 0.126 |
| SLC22A7/OAT2 | 0.302 | 0.412 ** | 0.270 | 0.325 | 0.214 |
| SLCO1B1/OATP1B1 | 0.295 | −0.030 | −0.071 | −0.392 | 0.179 |
| SLCO1B3/OATP1B3 | 0.519 * | 0.025 | −0.174 | −0.234 | 0.893 ** |
| SLCO2B1/OATP2B1 | −0.077 | 0.191 | −0.086 | 0.436 * | 0.214 |
* p < 0.05; ** p < 0.01; LLOQ—lower limit of quantification.