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. 2022 Jul 12;13:896558. doi: 10.3389/fendo.2022.896558

Figure 1.

Figure 1

Effect of lysophosphatidic acid (LPA) on human sperm motility. (A–C) Dose-dependent effects of LPA on sperm motility. Normal human spermatozoa were treated with LPA (0, 12.5, 25, 50, 100, and 200 µM) for 1 h and 3 h in the Biggers, Whitten, and Whittingham (BWW) medium. Parameters of sperm motility, VCL (A), ALH (B), and LIN (C), were examined using computer-assisted sperm analysis. Results are expressed as mean ± SEM (n = 6). *p < 0.05, **p < 0.01 as compared with the corresponding control (0 µM); VCL: curvilinear velocity; ALH: amplitude of lateral head displacement; LIN: linearity. (D) Effect of LPA (100 µM) on the VCL of spermatozoa from healthy individuals (n = 80) and patients with asthenozoospermia (n = 30). The motility was assessed after spermatozoa were treated with LPA (0 and 100 µM) for 1 h in the BWW medium. Results are expressed as mean ± SEM. ***p < 0.001 as compared with the corresponding control (0 µM).