Table 1. Initial patient characteristics anti-MOG cohort.

Patient	Onset age (gender)	Symptoms; duration (d)	Clinical findings	VA (RE, LE; logMAR)	RAPD (RE, LE)	Colour VA (Ishihara test; RE, LE)	Red desaturation (present, absent)	Average GCL; RE, LE (µm)	Average RNFL; RE, LE (µm)	Pain (retrobulbar or on movement)	MRI brain and orbits demyelination protocol	Initial treatment
1	41 (F)	Decrease in right VA; pain (7)	Normal ONH bilaterally	1.0, 0.6	+3, 0	0/14, 14/14	Present RE	65, 78	80, 104	On movement	High signal in retrobulbar optic nerves bilaterally that does not extend to chiasm	Admitted for 3/7 IVMP with oral taper
2	33 (F)	Blurring of vision BE; pain on eye movements (2)	Bilateral swollen ONH	1.0, 1.0	0, 0	0/14, 0/14	Present BE	84, 91	175, 205	On movement BE	High signal in optic nerves bilaterally.	Admitted for 3/7 IVMP with oral taper
3	36 (F)	Left orbital pain (11)	Normal RE ONH; LE ONH swollen inferiorly	0, 0.1	0, 0	14/14, 14/14	Absent BE	87, 85	104, 114	Retrobulbar	Irregular enhancement of left optic nerve. MRI spine NAD	Admitted for 3/7 IVMP with oral taper
4	37 (M)	Decrease in right VA; pain on eye movements (14)	Right swollen ONH	1.0, 0	+3, 0	0/14, 14/14	Present RE	83, 83	139, 91	On movement of RE only	Low grade thickening and enhancement of right optic nerve	Admitted for 3/7 IVMP with oral taper
5	23 (M)	Decrease in left VA; pain (7)	Pale left ONH	0, 2.1	0, +1	14/14, 1/14	Present LE	61, 61	59, 55	Retrobulbar RE	High signal in both retrobulbar optic nerves, more marked on left with enhancement	Admitted for 3/7 IVMP with oral taper
6	24 (M)	Decrease in left VA; pain (7)	Normal ONH bilaterally	0, 0.3	0, +2	14/14, 14/14	Present LE	87, 76	98, 94	Pain on eye movements LE	Abnormal T2 hyperintensity of left optic nerve which appears markedly atrophied	Admitted for 3/7 IVMP with oral taper
7	10 (M)	Decrease in left VA, followed by right VA and pain (10)	Swollen ONH bilaterally	1.8, 2.1	1, +3	1/14, 1/14	Present BE	32, 34	254, 379	Retrobulbar pain BE	Numerous bilateral asymmetric areas of abnormal signal intensity within the white matter sparing the corpus callosum	Admitted for 3/7 IVMP with oral taper
8	14 (M)	Decrease in left VA with pain (14)	Swollen left ONH	0.1, 1	0, +3	14/14. 3/14	Present LE	68, 73	92, 235	Pain on eye movement LE	Signal abnormality in the retrobulbar left optic nerve extending into the canalicular component. The nerve is expanded and demonstrates enhancement	Admitted for 3/7 IVMP with oral taper
9	21 (F)	Decrease left VA and eye pain (14)	Swollen left ONH	0, 0.2	0, +2	14/14, 7/14	Present LE	79, 80	93, 203	Pain on eye movement LE	T2 hyperintensity within the anterior aspect of the intraorbital segment of the left optic nerve	Admitted for 3/7 IVMP with oral taper
10	61 (F)	Decrease in right VA (3)	Swollen right ONH	0.5, 0.1	+2, 0	6/14, 12/14	Present RE	54, 49	58, 54	No pain	Increased signal from the retrobulbar and canalicular optic nerve	Presumed NAION, normal ESR, follow up OPD
11	19 (F)	Decrease in right VA and eye pain (7)	Swollen right ONH	0.4, 0	+3, 0	4/14, 14/14	Present RE	79, 83	143, 95	Pain on eye movements RE	Abnormal signal within the orbital segment of the right optic nerve which appears expanded	Admitted for 3/7 IVMP with oral taper
12	31 (F)	Pain on movement in RE (3)	Swollen right ONH	0, 0	+2, 0	13/14, 14/14	Present RE	33, 34	254, 379	Pain on eye movements RE	High signal within the intraorbital segment of the right optic nerve measuring 8 mm	Admitted for 3/7 IVMP with oral taper

F: Female; M: Male; VA: Visual acuity; ONH: Optic nerve heads; RAPD: Relative afferent pupillary defect; RE: Right eye; LE: Left eye; BE: Both eyes; GCL: Ganglion cell layer; RNFL: Retinal nerve fibre layer; MRI: Magnetic resonance imaging; NAD: No abnormality detected; IVMP: Intravenous methylprednisolone; NAION: Nonarteritic anterior ischemic optic neuropathy; ESR: Erythrocyte sedimentation rate; OPD: Outpatient department.