Figure 1.

TRPCs function in stem cells. TRPC1-induced Ca²⁺ influx activates the FGF/FGFR1 signaling pathway or OTX2 to promote proliferation or differentiation of NSCs. TRPC3 triggers Ca²⁺ influx in mitochondria, which promotes the stabilization of differentiation processes of ESCs to NSCs. High expression of TRPC5 in A2B5⁺ NPCs with increased store-operated Ca²⁺ entry promotes cell differentiation. Further, the dynamic distribution of TRPC6 can control the magnitude of store-operated Ca²⁺ entry via changes in membrane potential to regulate the cell cycle of BMSCs.