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. 2022 Jul 14;11(14):4080. doi: 10.3390/jcm11144080

Table 1.

Immunosuppressants effects on cardiovascular risk factors.

Immunosuppressants CV Risk Factors Exacerbated
Corticosteroids Prednisone Hyperglycemia (+++),
Arterial hypertension (++),
Triglycerides (++), LDL (++).
Deflazacort Hyperglycemia (+),
Arterial hypertension (++),
Triglycerides (+), LDL (+).
Calcineurin Inhibitors Cyclosporine Hyperglycemia (+),
Arterial hypertension (+++),
Triglycerides (++), LDL (+++).
Tacrolimus Hyperglycemia (+),
Arterial hypertension (+++),
Triglycerides (+), LDL (++).
mTOR Inhibitors Sirolimus Triglycerides (+++), LDL (+++).
Everolimus Triglycerides (+++), LDL (+++).
Antiproliferative Agents Azathioprine No significant increase
Mycophenolate Mofetil No significant increase

mTOR: mammalian target of rapamycin. (+): mild increase; (++): moderate increase; (+++) severe increase. The magnitude of the effect was arbitrarily estimated by the authors according to the evidence discussed in this review.