Figure A2.

Experimental scheme of the treatment with ObiDi and obinutuzumab in a mouse lymphoma model. At day –14, SCID CB17 mice received luciferase-transduced Raji cells (0.25 × 10⁶) intravenously. Two weeks later, mice received either (i) 15 µg SO1861 in 100 µL PBS subcutaneously into the neck in combination with 1.8 µg ObiDi in 100 µL PBS intraperitoneally 1 h later, (ii) 1.8 µg ObiDi as in experiment (i), (iii) 1.8 µg Obinutuzumab in 100 µL PBS intraperitoneally or (iv) 100 µL PBS as mock-treated control. The mice were alternately treated every three and four days for four weeks. The live imaging to visualize tumors was conducted every week for six weeks.