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. Author manuscript; available in PMC: 2023 Jul 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2022 May 2;446:116042. doi: 10.1016/j.taap.2022.116042

Figure 2.

Figure 2.

ATM activation is significantly reduced in iAs-exposed HaCaT cells. A. Immunoblot for ATM pathway signaling (ATM and CHEK2) and ATR activation in quadruplicate HaCaT cell cultures exposed to 0 or 100 nM sodium arsenite for 7 weeks. B. Densitometric analysis of ATM activation (ATM-pSer1981/t-ATM). C. Densitometric analysis of CHEK2 activation (CHEK-2pThr68/t-CHEK2). D. Densitometric analysis of ATR activation (ATR-pSer428/t-ATR). Statistical analysis completed by unpaired two-tailed t-test; *p ≤ 0.05